Effect of sitagliptin on insulin secretion and glucose metabolism in Japanese patients with type 2 diabetes mellitus

Effect of sitagliptin on insulin secretion and glucose metabolism in Japanese patients with type 2 diabetes mellitus - Effect of sitagliptin on insulin secretion and glucose metabolism in Japanese patients with type 2 diabetes mellitus

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000006401

Enrollment

Registered

2011-09-24

Start date

2011-09-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

type 2 diabetes mellitus

Interventions

examination with the use of stable isotope-labelled glucose

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Japanese patients with hemoglobin A1c (JDS) level 6.5% and higher under antidiabetic treatment with lifestyle modification and/or oral hypoglycemic agents (sulfonylureas, biguanides, thiazolidinediones, and/or alpha-glucosidase inhibitors)

Exclusion criteria

Exclusion criteria: 1) type 1 diabetes mellitus 2) history of severe ketosis, diabetic coma, or pre-coma within six months 3) severe infection, pre- or post-surgery, or severe trauma 4) renal dysfunction with serum creatinine >= 1.5 mg/dl in males or 1.3 mg/dl in females 5) body mass index >= 40 kg/m2 6) women who are pregnant, breast-feeding, or suspected of being pregnant 7) history of hypersensitivity to the investigational medication 8) patients whose participation in the current trial is evaluated as being inadequate by the doctor

Design outcomes

Primary

Measure	Time frame
the change of glucose metabolism and insulin secretion evaluated with the use of stable isotope tracers and hyperglycemic clamp technique	—

Countries

Japan

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026