A randomized clinical trial for the efficacy and safety of local steroid injection for prevention of post-ESD esophageal stenosis

A randomized clinical trial for the efficacy and safety of local steroid injection for prevention of post-ESD esophageal stenosis - A RCT of local steroid injection for prevention of post-ESD esophageal stenosis

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000006327

Enrollment

Registered

2011-09-15

Start date

2010-02-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Early esophageal cancer

Interventions

Local steroid injection (Triamcinolone Acetonide) after ESD No treatment after ESD

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with superficial squamous cell carcinoma whose mucosal defect after ESD is expected to be over three-fourths of the whole circumference (being highly associated with post ESD stenosis)

Exclusion criteria

Exclusion criteria: Excluded if patients have: 1. previous therapy experience 2. steroid treatment for other diseases 3. esophageal adenocarcinoma 4. swallowing difficulty

Design outcomes

Primary

Measure	Time frame
The proportion of patients who need endoscopic dilatation for post-ESD esophageal stenosis	—

Secondary

Measure	Time frame
1. The frequency of the complication with local steroid injection 2. The frequency of the complication with endoscopic dilatation	—

Countries

Japan

Contacts

Public ContactHiroaki Takahashi

Keiyukai Sapporo Hospital Dept. of Gastroenterology

hiroaki@sapmed.ac.jp011-863-2101

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026