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Study of the effect of Proton Pump Inhibitor (PPI) on intra-gastric pH in healthy volunteer - Comparison of Esomeprazole and Rabeprazole -

Study of the effect of Proton Pump Inhibitor (PPI) on intra-gastric pH in healthy volunteer - Comparison of Esomeprazole and Rabeprazole - - Study of the effect of Proton Pump Inhibitor (PPI) on intra-gastric pH in healthy volunteer - Comparison of Esomeprazole and Rabeprazole -

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000006319
Enrollment
24
Registered
2011-10-01
Start date
2011-10-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastroesophageal Reflux Disease(GERD)

Interventions

Esomeprazole20mg post breakfast for a week over a week - Rabeprazole10mg post breakfast for a week- over a week- Placebo post breakfast for a week Esomeprazole20mg post breakfast for a week- over a we

Sponsors

Shimane University Faculty of Medicine, Department of Gastroenterology and Hepatology
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1)healthy adults 2)subjects with written informed consent

Exclusion criteria

Exclusion criteria: 1)Subjects with a history of allegy for esomeprazole or rabeprazole 2)Subjects during taking atazanavir sulfate 3)Subjects with a history of drug allegy 4)Diseases in heart, liver and kidney 5)Subjects with a history of allegy for anesthetic drug 6)Subjects with a history of gastrectomy and/or vagotomy 7)H. pylori infection were confirmed positive 8)Subjects currently have the disease during treatment 9)other not applicatable person recognized by a doctor

Design outcomes

Primary

MeasureTime frame
evaluation of the gastric pH post 1 week administration of esomeprazole or rabeprazole—

Countries

Japan

Contacts

Public Contactkenji Furuta

Shimane University Faculty of Medicine Department of Gastroenterology and Hepatology

0853-20-2190

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026