Optimization of methods to suppress afterdischarges in direct cortical electrical stimulation

Optimization of methods to suppress afterdischarges in direct cortical electrical stimulation - Optimization of methods to suppress afterdischarges in direct cortical electrical stimulation

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000006313

Enrollment

Registered

2011-11-01

Start date

2011-11-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Epilepsy

Interventions

Brief pulse cortical stimulation will be added in order to suppress afterdischarges induced by direct cortical stimulation. Intensity and frequency of brief pulse cortical stimulation will be equival

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Medically intractable epilepsy patients undergoing subdural and/or depth electrode implantation for possible epilepsy or lesion surgeries.

Exclusion criteria

Exclusion criteria: When an informed consent is not obtained.

Design outcomes

Primary

Measure	Time frame
Electroencephalographic data during and after direct cortical electrical stimulation is to be analyzed. Statistical methods such as Student's t-test or analysis of variance will be used to analyze parameters such as the rate of afterdischarge suppression, interval between the stimulation which induced afterdischarges and a brief pulse cortical stimulation, and the duration of brief pulse cortical stimulation. Spectrogram is to be used to analyze the relationship between frequency changes of electroencephalographic waveform and timing of a brief pulse cortical stimulation.	—

Measure

Time frame

Electroencephalographic data during and after direct cortical electrical stimulation is to be analyzed. Statistical methods such as Student's t-test or analysis of variance will be used to analyze parameters such as the rate of afterdischarge suppression, interval between the stimulation which induced afterdischarges and a brief pulse cortical stimulation, and the duration of brief pulse cortical stimulation. Spectrogram is to be used to analyze the relationship between frequency changes of electroencephalographic waveform and timing of a brief pulse cortical stimulation.

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Countries

Japan

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026