acute ischemic stroke
Conditions
Interventions
Early statin group: atorvastatin 10mg/day immediately after the entry (<
48hrs after onset). Statin treatment may be initiated via nasal tube in patients with swallowing difficulty.
Delyed statin group: atorvastatin 10mg/day 14days after the entry
Sponsors
Department of Neurology, St. Marianna University School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Entry criteria 1. ischemic stroke defined by MRI-DWI. 2. <48 hours after onset 3. Patients have dyslipidemia.
Exclusion criteria
Exclusion criteria: Exclusion criteria 1. statin treatment within 3 months 2. chronic devastating illness 3. stroke caused by arterial dissection, or moyamoya disease 4. acute ischemic heart disease, severe inflammatory disease, autoimmune disease, collagen disease or malignancy requiring treatment 5. pregnancy or possibility of pregnancy 6. recurrent cerebral infarction that had developed 6 months after the previous episode 7. disability with modified Rankin scale (mRS) score &#8805;2 before onset 8.steroid or NSAID treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Progression in stroke deficits within 14 days(NIHSS>4) 2. Changes in proinfalmmatory biomarkers; hsCRP, IL-6, IL-10, IL-18, MMP-2, MMP-9, TNF-alpha at Day-1,Day-3, Day-7, Day14. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. infarct volume 2. mRS<2 at 90 days | — |
Countries
Japan
Contacts
Public ContactYasuhiro Hasegawa
St. Marianna University School of Medicine Department of Neurology
Outcome results
None listed