Analysis for the change of the intestinal bacterial flora by antimicrobials (antibiotics) with using T-RFLP method, and examination of the usefulness of probiotics for diarrhea caused by antimicrobials.

Analysis for the change of the intestinal bacterial flora by antimicrobials (antibiotics) with using T-RFLP method, and examination of the usefulness of probiotics for diarrhea caused by antimicrobials. - Analysis for the change of the intestinal bacterial flora by antimicrobials (antibiotics) with using T-RFLP method, and examination of the usefulness of probiotics for diarrhea caused by antimicrobials.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000006261

Enrollment

120

Registered

2011-09-01

Start date

2011-08-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with nonsevere of acute pharyngitis, acute bronchitis, otitis media, etc. who need antimicrobials treatment.

Interventions

Probiotics administration group : Bio-Three powder or Bio-Tree tablets 6 months ~ less than 3 years : 0.5g t.i.d or 1 tablet t.i.d 3 years ~ less than 15 years : 1.0g t.i.d or 2 tablets t.i.d Non

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.Patients with nonsevere of acute pharyngitis, acute bronchitis, otitis media, etc. who need antimicrobials treatment. 2.Patients whose representatives have submitted the letter of consent. 3.Patients who can observe this protocol.

Exclusion criteria

Exclusion criteria: 1.Patients with diarrhea before administration. 2.Patients who received antimicrobials administration within one week before administration. 3.Patients with chronic, immunity system and serious diseases. 4.Patients who are applicable for chemotherapy, immunostimulation therapy, radiotherapy or surgery. 5.Patients with critical liver and kidney disorders and heart diseases, which may affect drug safety. 6.Patients with drug allergy. 7.Others; Patients who are judged as inappropriate for this test by lead principal investigator or contributing investigators.

Design outcomes

Primary

Measure	Time frame
Incidence of diarrhea	—

Secondary

Measure	Time frame
Analysis of the intestinal bacterial flora by T-RFLP method	—

Countries

Japan

Contacts

Public ContactToru Igarashi

Nippon Medical School Hospital Department of Pediatrics

iga@nms.ac.jp03-3822-2131

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026