The Effect of Valproate on the Required Dose of Propofol for Sedation in Patients With Mental Retardation

The Effect of Valproate on the Required Dose of Propofol for Sedation in Patients With Mental Retardation - Effect of Valproate on Propofol

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000006228

Enrollment

Registered

2011-08-25

Start date

2009-02-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with oral valproate

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: American Society of Anesthesiologists (ASA) physical status is 1 or 2. The dental treatment plan had been prepared. Patients had moderate or severe Mental Retardation, and were not completely cooperated with dental treatment.

Exclusion criteria

Exclusion criteria: Patients can communicate and cooperate with dental treatment. Patients need premedication and inhalational anesthetics. ASA physical status is 3 or 4. The complications are not controlled by oral drugs. There is a tendency of somnolence before treatment due to the influence of medicine. Patients have oral antiepileptic or psyhotropic drug medication excluding valproate

Design outcomes

Primary

Measure	Time frame
The required dose of propofol	—

Countries

Japan

Contacts

Public ContactMinako ishii

Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Siences Department of Dental Anesthsiology and Special Care Dentistry

086-235-6721

Outcome results