Clarification of pathophysiological roles of prorenin and (pro)renin receptor in hypertension, endocrine disorders and metabolic disorders

Clarification of pathophysiological roles of prorenin and (pro)renin receptor in hypertension, endocrine disorders and metabolic disorders - Clarification of pathophysiological roles of prorenin and (pro)renin receptor in diseases

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000006222

Enrollment

2000

Registered

2011-10-01

Start date

2011-10-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hypertension endocrine disorders metabolic disorders

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patient who fulfills more than one of the diagnostic criteria of hypertension, endocrine disorders and metabolic dis orders 2. Patient who has been signed the consent form after sufficiently informed and fully understood the study

Exclusion criteria

Exclusion criteria: 1. Patient with chronic kidney disease (CKD) stage 4 or 5 2. Patient whom director of the study disqualified

Design outcomes

Primary

Measure	Time frame
plasma/urine levels of prorenin and soluble (pro)renin receptor	—

Secondary

Measure	Time frame
1. Blood tests: biochemical measurements, hormones, oxidative stress markers, inflammatory markers, renin 2. Urine tests: pH, albumin/creatinine, hormones, oxidative stress markers, renin 3. Imaging tests: X-rays, CT, MRI, echography 4. Physiological tests: ECG, flow-mediated dilataion(FMD), cardio-anke vascular index(CAVI), augmentaion index(AI), ankle-brachial index(ABI), 24 hours ambulatory blood pressure monitoring(ABPM), visceral/subcutaneous fat ratio measurement	—

Measure

Time frame

1. Blood tests: biochemical measurements, hormones, oxidative stress markers, inflammatory markers, renin 2. Urine tests: pH, albumin/creatinine, hormones, oxidative stress markers, renin 3. Imaging tests: X-rays, CT, MRI, echography 4. Physiological tests: ECG, flow-mediated dilataion(FMD), cardio-anke vascular index(CAVI), augmentaion index(AI), ankle-brachial index(ABI), 24 hours ambulatory blood pressure monitoring(ABPM), visceral/subcutaneous fat ratio measurement

—

Countries

Japan

Contacts

Public ContactKanako Bokuda

Tokyo Women's Medical University Department of medicine II

kanakobkd@endm.twmu.ac.jp03-3353-8111

Outcome results