Difference in effect on post-meal lipid, proinsulin, GIP and GLP-1 between Sitagliptin, Vildagliptin and Alogliptin in T2DM using DPP-4 inhibitor

Difference in effect on post-meal lipid, proinsulin, GIP and GLP-1 between Sitagliptin, Vildagliptin and Alogliptin in T2DM using DPP-4 inhibitor - Clinical study of DPP-4 inhibitor therapy on post meal lipid, proinsulin, GIP and GLP-1

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000006217

Enrollment

Registered

2011-09-01

Start date

2011-09-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 Diabetes Mellitus

Interventions

Sitagliptin 50mg/day for 3 month Vildagliptin 100mg/day for 3 month Alogliptin 25mg/day for 3 month

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1)Type 2 Diabetes Mellitus (HbA1c level: more than 6.5%, less tess than 10.0%) 2)Patients with written IC

Exclusion criteria

Exclusion criteria: 1)Patients who use of other DPP4 inhibitor 2)Patients who use of fibrate 3)Diabetic neuropathy 4)Severe ketosis,deabetic coma or precoma,type1diabetes 5)Severe renal dysfunction requiring hemodialysis or peritoneal dialysis 6)Severe hepatic dysfunction 7)Patients with a history of hypersensitibity to the study drug 8)Patients before or after operation, and those with severe infections or serious injury 9)Pregnant 10)Patients judged by the investigator to be ineligible for some other reason

Design outcomes

Primary

Measure	Time frame
Lipid profile(pre-and post-meal(30min,1,2,3hours)triglyceride, pre- and post-meal(30min,1,2,3hours)chylomicron, pre- and post-meal(30min,1,2,3hours)VLDL, pre- and post-meal(30min,1,2,3hours)IDL, pre- and post-meal(30min,1,2,3hours)native LDL, pre- and post-meal(30min,1,2,3hours)small dense LDL, pre- and post-meal(30min,1,2,3hours)HDL	—

Secondary

Measure	Time frame
HbA1c, pre- and post-meal blood glucose(30min,1,2,3hours), pre-and post-meal(30min,1,2,3hours)insulin, pre- and post-meal(30min,1,2,3hours)proinsulin, pre- and post-meal(30min,1,2,3hours)C-peptide , pre- and post-meal(30min,1,2,3hours)GLP-1, pre- and post-meal(30min,1,2,3hours)GIP, pre- and post-meal(30min,1,2,3hours)glucagon	—

Countries

Japan

Contacts

Public ContactIkuo Inoue

Saitama Medical University Hospital Dept. of Endocrinplogy and Diabetology

i1901018@saitama-med.ac.jp049-276-1875

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026