Smokers, nonsmokers
Conditions
Interventions
<
Smoking of subject'
s usual cigarette brand (on site, for 2 days) =>
Smoking of A-705 (on site, for 28 days) =>
Smoking of A-705 (at home, for 28 days)
<
Use of A-805 (on site, for 28 days)
<
Smoking of a conventional tobacco product (on site, for 28 days) =>
Smoking of a conventional tobacco product (at home, for 28 days)
<
Sponsors
JAPAN TOBACCO INC.
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. Subjects who sign the study-specific consent form 2. Subjects who are confirmed to be in good health through the screening process 3. For smokers, subjects who do not plan to quit smoking over the study period 4. For nonsmokers, subjects who do not plan to use tobacco products over the study period etc.
Exclusion criteria
Exclusion criteria: 1. Subjects who have regular use experience of hand-rolled cigarette, cigarillo, cigar, pipe, smokeless tobacco or chewing tobacco 2. Subjects who donate 200ml or more of blood within 4 weeks before screening, or who donate 400ml or more of blood within 12 weeks before screening (including blood donation) or subjects who donate plasma or platelet within 4 weeks before screening etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To investigate the change of biomarkers in healthy adult male smokers on site during four-week use of various types of tobacco in comparison with a conventional tobacco product | — |
Countries
Japan
Outcome results
None listed