A clinical study to investigate the efficacy of diuretics to the HF patients with proteinuria and edema.

A clinical study to investigate the efficacy of diuretics to the HF patients with proteinuria and edema. - A clinical study to investigate the efficacy of diuretics to the HF patients with proteinuria and edema.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000006212

Enrollment

Registered

2011-08-22

Start date

2011-08-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart Failure

Interventions

tolvaptan 7.5mg/day (can be escalated to 15mg, if needed)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.patients who satisfy inclusion criteria as follows at the screening test 2.congestive heart failure patients who are already administered diuretics 3.patients with proteinuria and edema 4.inpatients

Exclusion criteria

Exclusion criteria: 1.patients who have a history of allergens against tolvaptan or similar compounds 2.anuric patients (urinary output: <100mL/day) 3.patients who cannnot feel thirsty or have difficulty to drink 4.patients whose serum sodium level is over 147mEq/L 5.pregnant or possibly pregnant woman

Design outcomes

Primary

Measure	Time frame
Body weight	—

Secondary

Measure	Time frame
edema CTR Ejection fraction plasma BNP level	—

Countries

Japan

Contacts

Public ContactKazo Kaizu

Social Insurance Yokohama Central Hospital Department of Nephrology and Blood purification

045-641-1921

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026