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Molecular alterations in Barrett's esophagus by the treatment with proton pump inhibitors or Helicobacter pylori eradication

Molecular alterations in Barrett's esophagus by the treatment with proton pump inhibitors or Helicobacter pylori eradication - Molecular alterations in Barrett's esophagus and the treatment with PPIs or H. pylori eradication

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000006207
Enrollment
38
Registered
2011-08-21
Start date
2010-07-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Barrett&#39

Interventions

H. pylori un-eradicated group (H. pylori positive case) H. pylori eradicated group (H. pylori positive case) PPI un-treated group (H. pylori negative case) PPI treated group (H. pylori negative case)

Sponsors

Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patients with Barrett's esophagus diagnosed by endoscopy

Exclusion criteria

Exclusion criteria: (1)Patients with malignancy in other organs (2)Patients with having allergy to PPIs or drugs used for H. pylori eradication (3)Patients who are regularly taking PPIs or non-steroidal anti-inflammatory drugs (4)Past episode of H. pylori treatment (5)Patients with having a past history of esophagectomy or gastrectomy (6)Patients who have determined by the physicians to have any reasons of unqualified

Design outcomes

Primary

MeasureTime frame
Changes of biomarkers related to pathogenesis of Barrett's esophagus are evaluated at baseline and 1-yr after intervention with/without PPI administration in H. pylori negative patients and H. pylori eradication in H. pylori positive patients—

Countries

Japan

Contacts

Public ContactJiro Watari

Hyogo College of Medicine Division of Gastroenterology, Department of Internal Medicine

watarij@hyo-med.ac.jp0798-45-6662

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026