osteoarthritis of knee
Conditions
Interventions
NS:Non-steriodal anti-inflammatory drugs (NSAIDs) celecoxib, 200mg/day for 12 weeks
HA:intra-articular injecion of hyaluronate acid high molecular weight 2700kDa HA, 5 times with one week interval
EX
Sponsors
Juntendo Tokyo Koto Geriatric Medical Center
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: patients with osteoarthritis of the knee (Kellgren/Lawrence stage II III IV )
Exclusion criteria
Exclusion criteria: 1) Patients who had treatment for their knee at other hospital or clinic, i.e., who received therapeutic exercise, intraarticular injection, or NSAIDs within 4 weeks before the day to start the trial. 2) Patients who had done or planned operation against the knee. 3) Patients who have diseases requiring regular or intermittent use of steroid or non-steroidal anti-inflammatory drugs. 4) Patients who have articular cartilage injury or history of damage due to obvious trauma or septic arthritis. 5) Patients who were diagnosed as rheumatoid arthritis, gout, pseudogout, or collagen diseases. 6) Patients with cardiac, liver, or renal dysfunction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) Japanse Knee Osteoarthritis Measure: JKOM 2) measurement of values of blood count, ESR, hs-CRP, HA, IL-6, IL1ra 3)Self-rating Depression Scale:SDS 4)Timed Up and Go Test, Timed one foot standing test | — |
Countries
Japan
Contacts
Public ContactYukio Shimura
Juntendo Tokyo Koto Geriatric Medical Center Orthopeadics
Outcome results
None listed