Goal-Oriented Therapy Evaluated By Cardiopulmonary Exercise Testing For Pulmonary Arterial Hypertension

Goal-Oriented Therapy Evaluated By Cardiopulmonary Exercise Testing For Pulmonary Arterial Hypertension - GOOD EYE

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000006174

Enrollment

Registered

2011-08-15

Start date

2011-09-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pulmonary arterial hypertension

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Age lower limited 16 years old, upper limited 85 years old 2) Mean pulmonary arterial pressure at rest was more than eual to 25 mmHg and pulmonary capillary wedge pressure less than equal to 15 mmHg by Swan-Ganz catheterization 3) No abnormal ventilation/perfusion scan

Exclusion criteria

Exclusion criteria: 1) Pulmonary hypertension due to left heart disease, Pulmonary hypertension due to lung diseases and/or hypoxia, Chronic thromboembolic pulmonary hypertension 2) Pregnant 3) Moderate or severe hepatic failure patients 4) More than 2.0 mg/dl Serum creatinine levels 5) Severe interstitial lung disease 6) Coronary artery disease 7) The patients can not walk by themself. 8) The patients who have taken medications for PAH treatment drugs including the pill PGI2, endothelin receptor antagonists, phosphoesterase inhibitors-5, and intravenous epoprostenol 9) Inappropriate patients due to other reasons

Design outcomes

Primary

Measure	Time frame
Admission due to right heart failure, syncope, arrythmia, and hemoptysis. induction of intravenous epopresterol. Cardiac death.	—

Secondary

Measure	Time frame
Exercise tolerance (cardiopulmonary exercise testing, 6-minutes walk distance, WHO functional class, hemodynamics, BNP, QOL score by HADS, SF-8, and PMADL 8. induction of oxygen therapy	—

Countries

Japan

Contacts

Public ContactAkihiro Hirashiki

Nagoya University Graduate School of Medicine Department of Advanced Medicine in Cardiopulmonary Disease

hirasiki@ncgg.go.jp052-744-0388

Outcome results