The study to evaluate the efficacy of lymph node dissection around the inferior mesenteric artery with preservation of the left colic artery for rectal cancer

The study to evaluate the efficacy of lymph node dissection around the inferior mesenteric artery with preservation of the left colic artery for rectal cancer - The efficacy of lymph node dissection with preservation of the left colic artery for rectal cancer

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000006160

Enrollment

1460

Registered

2011-09-01

Start date

2011-10-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rectal Cancer

Interventions

lymph node dissection around the inferior mesenteric artery without preservation of the left colic artery lymph node dissection around the inferior mesenteric artery with preservation of the left coli

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Histologically proven rectal adenocarcinoma 2) Distal extent of tumor must be in the rectum (within 15cm from the anal verge as determined via endoscopy or confirmed by barium enema or sagittal slice of MRI/CT) 3) Clinical Stage Tumor depth of invasion: T2, T3 or T4 Lymph node metastasis: N0, N1, N2 or N3 No distant metastasis: M0 4) Age more than 20years old 5) Elective (low) anterior resection with lymph node dissection around the inferior mesenteric artery 6) No previous surgery for middle colic artery or inferior mesenteric artery 7) Preserved organ function within 6 weeks before registraion White blood cell count>=3,000/ul Platelet cpunt>=100,000/ul GOT<=100 IU/L GPT<=100 IU/L Total bilirubin<=2.0 mg/dl Creatinine<=1.5 mg/dl 8) written informed consent

Exclusion criteria

Exclusion criteria: 1) Synchronous colorectal carcinoma 2) Pregnant women, possibly pregnant women, and nursing mothers 3) Complicated with psychosis 4) Myocardial infarction within six months or unstable angina 5) Severe pulmonary emphysema or pulmonary fibrosis 6) Uneder systemic steroid therapy 7) Required for a intersphincteric resection 8) Other conditions not suitable for this study

Design outcomes

Primary

Measure	Time frame
Incidence of anastomotic leakage	—

Secondary

Measure	Time frame
Conversion rate in lymph node dissection around the inferior mesenteric artery with preservation of the left colic artery 3-year disease-free survival Exploratory study of the risk factor for anastomotic leakage	—

Countries

Japan

Contacts

Public ContactMasataka Ikeda Tsunekazu Mizushima

Osaka University Graduate School of Medicine Department of Surgery

tmizushima@gesurg.med.osaka-u.ac.jp06-6879-3251

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026