Effect of grapefruit juice on activities of metabolic enzyme and transporter in healthy volunteers.

Effect of grapefruit juice on activities of metabolic enzyme and transporter in healthy volunteers. - Effect of grapefruit juice on activities of metabolic enzyme and transporter in healthy volunteers.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000006072

Enrollment

Registered

2011-07-29

Start date

2011-08-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

healthy volunteers

Interventions

oral administration of celiprolol, midazolam and grapefruit juice

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: capable of understanding and adhering to the protocol

Exclusion criteria

Exclusion criteria: Blood pressure <= 100 mmHg Heart rate <= 50 mmHg Abnormality on laboratery tests and ECG Continual intake of drug or supplement Patients with chronic asthma and diabetic mellitus

Design outcomes

Primary

Measure	Time frame
pharmacokinetics of celiprolol and midazolam, blood pressure, heart rate	—

Countries

Japan

Contacts

Public ContactShinya Uchida

University of Shizuoka, School of Pharmaceutical Sciences Department of Pharmacy Practice & Science

054-264-5234

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026