Pharmacokinetic interaction between high dose catechin-contained green tea and midazolam

Pharmacokinetic interaction between high dose catechin-contained green tea and midazolam - Green tea-midazolam interaction study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000006067

Enrollment

Registered

2011-08-01

Start date

2011-08-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy volunteers

Interventions

Subjects consume 700 mL of high catechin-contained green tea every day for 13 days. On day 14, subjects are administered midazolam (5 microg/kg) intravenously just after green tea intake. On day 15, s

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Healthy adults

Exclusion criteria

Exclusion criteria: Smoker

Design outcomes

Primary

Measure	Time frame
Pharmacokinetics of midazolam and 1'-hydroxy midazolam	—

Countries

Japan

Contacts

Public ContactKazuhiko Takeuchi

Hamamatsu University School of Medicine Department of Clinical Pharmacology and Therapeutics

takeutik@hama-med.ac.jp053-435-2385

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026