The relation of cytokine concentration in epithelial lining fluid and in peripheral blood HLA-DR during esophagectomy &#8211;about the local inflammation and the relation to the systemic inflammation in the stressful surgical procedures for patients-

The relation of cytokine concentration in epithelial lining fluid and in peripheral blood HLA-DR during esophagectomy &#8211;about the local inflammation and the relation to the systemic inflammation in the stressful surgical procedures for patients- - The relation of cytokine concentration in epithelial lining fluid and in peripheral blood HLA-DR during esophagectomy &#8211;about the local inflammation and the relation to the systemic inflammation in the stressful surgical procedures for patients-

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000006062

Enrollment

100

Registered

2011-07-29

Start date

2011-08-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

esophageal cancer

Interventions

We used a bronchoscopic microsampling method to obtain epithelial lining fluid from lungs during esophagectomy.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Written informed concent

Exclusion criteria

Exclusion criteria: Exclusion criteria included cardiac disease categorized as NYHA classes 2-4;preoperative severe impairment of respiratory function,such as a vital capacity of <50% or a forced expiratory volume in one second of <50% of that predicted;pre-existing coagulopathy or thrombocytopenia;and preoperative nonsurgical supplemental treatments such as immunotherapy.Patients were excluded if they had systemic or local active infections.

Design outcomes

Primary

Measure	Time frame
Blood and epithelial lining fluid cytokine(IL-1beta,IL-6,IL-8,IL-10,TNFalpha,sICAM1,NFkappaB,) HLA-DR expression on monocytes	—

Countries

Japan

Contacts

Public ContactSaiko Wakabayashi

Juntendo University School of Medicine Department of Anesthesiology and Pain Medicine

03-3813-3111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026

The relation of cytokine concentration in epithelial lining fluid and in peripheral blood HLA-DR during esophagectomy &amp;#8211;about the local inflammation and the relation to the systemic inflammation in the stressful surgical procedures for patients-