Impact of comprehensive cardiac rehabilitation program on regression of atherosclerotic plaque and vascular remodeling

Impact of comprehensive cardiac rehabilitation program on regression of atherosclerotic plaque and vascular remodeling - Impact of exercise therapy on regression of atherosclerotic plaque and vascular remodeling

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000006038

Enrollment

Registered

2011-07-25

Start date

2009-11-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ischemic heart disease

Interventions

comprehensive cardiac rehabilitation program (the nonpharmacologic therapy that is the combination of the therapeutic exercise and the dietary instruction)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.Acute coronary syndrome patient 2.Patient that coronary artery plaque exists in leaving from area of the body treated by 5mm or more and same branches 3.Patient who obtained document agreement by intention of patient himself

Exclusion criteria

Exclusion criteria: 1.Target lesion is bypass graft. 2.Cardiogenic shock 3.Acute exacerbation, cirrhosis, and liver carcinoma of acute hepatitis and chronic hepatitis 4.The renal dysfunction (The serum creatinine value is 2.0mg/dL or more) or the dialytic treatment is being enforced. 5.Patient who judged that examination responsibility doctor is improper as object in present study

Design outcomes

Primary

Measure	Time frame
Change rate and remodeling index of capacity of coronary artery plaque after six months	—

Secondary

Measure	Time frame
1.Amount of change of capacity of coronary atherosclerotic plaque 2.Quality change of coronary atherosclerotic plaque 3.Amount of change and change rate of lipid profile 4.Correlation of serum lipid profile value after exercise therapy, the change rate, change of capacity of coronary atherosclerotic plaque rate, quality change, and remodeling index 5.Correlation of value of inflammatory marker after exercise therapy, the change rate, and change of capacity of coronary atherosclerotic plaque rate 6.Correlation of change rate, amount, amount of plague change, and change rate of adeponekuchin 7.Amount of change and change rate of area of coronary atherosclerotic plaque of culprit lesion 8.Minimum blood vessel diameter of culprit lesion, amount of change of percent of stenosis, and change rate 9.Major adverse cardio-cerebro-vascular events 10.All cause death	—

Measure

Time frame

1.Amount of change of capacity of coronary atherosclerotic plaque 2.Quality change of coronary atherosclerotic plaque 3.Amount of change and change rate of lipid profile 4.Correlation of serum lipid profile value after exercise therapy, the change rate, change of capacity of coronary atherosclerotic plaque rate, quality change, and remodeling index 5.Correlation of value of inflammatory marker after exercise therapy, the change rate, and change of capacity of coronary atherosclerotic plaque rate 6.Correlation of change rate, amount, amount of plague change, and change rate of adeponekuchin 7.Amount of change and change rate of area of coronary atherosclerotic plaque of culprit lesion 8.Minimum blood vessel diameter of culprit lesion, amount of change of percent of stenosis, and change rate 9.Major adverse cardio-cerebro-vascular events 10.All cause death

—

Countries

Japan

Contacts

Public ContactKatsumi Miyauchi

School of Medicine Juntendo University Department of Cardiovascular Medicine

ktmmy@juntendo.ac.jp03-3813-3111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026