Patients undergoing cardiac surgery with CPB, patients undergoing off-pump coronary artery bypass graft surgery, and healthy volunteers.
Conditions
Interventions
Patients undergoing coronary artery bypass graft with cardiopulmonary bypass
Patients undergoing coronary artery bypass graft without cardiopulmonary bypass
Sponsors
Dept Anesthesiology, Kyoto Prefectural University of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients with or without cardiopulmonary bypass were American Society of Anesthesiologists Physical Status class 3 or 4, and were aged 20-80 years.
Exclusion criteria
Exclusion criteria: We excluded patients and volunteers with conditions known or suspected to independently increase platelet activity; specifically, those with venous thrombosis, sepsis, acute infection, pregnancy, acute coronary syndromes, heparin-induced thrombocytopenic purpura, transient ischemic attacks, severe hypertension (>160/95 mmHg), recent cardiopulmonary bypass, or multiple sclerosis, preoperative hepatic, renal dysfunction, or severe respiratory disease. We also excluded patients who had received platelet transufusion perioperatively, or patients who could not discontinue aspirin 1 week before surgery and other non-steroidal anti-inflammatory medication at least 48 h preoperatively.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intraplatelet Bax increases after cardiopulmonary bypass contributes to reduced perioperative platelet-surface GPIb expression and platelet dysfunction during the perioperative period. | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in intraplatelet Bax and related pathways are less pronounced during and after off-pump cardiac procedures than for cardiopulmonary bypass. | — |
Countries
Japan
Contacts
Public ContactYasufumi Nakajima
Kyoto Prefectural University of Medicine Anesthesiology
Outcome results
None listed