Schizophrenia
Conditions
Interventions
continuous D2 blockade of >
65%. Subjects will be treated with an individually prepared regimen and observed for one year.
Intermittent D2 blockade of >
65%. Subjects will be treated with an individually prepared regimen and observed for one year.
Sponsors
Keio University, School of Medicine Department of Neuropsychiatry
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) DSM-IV diagnosis of schizophrenia or schizoaffective disorder (2) Having received a stable dose of risperidone or olanzapine for previous 3 months
Exclusion criteria
Exclusion criteria: (1) Receiving another antipsychotic drug (2) History of treatment with long-acting risperidone within 6 months (3) Past history of vagus nerve reflection with a blood test
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Positive and Negative Syndrome Scale (PANSS), Simpson-Angus Scale (SAS), Barnes Akathisia Rating Scale (BAS), Abnormal Involuntary Movement Scale (AIMS), Japanese version of the Calgary Depression Scale for Schizophrenics (JCDSS), Subjective Well-being under Neuroleptic drug treatment Short form, Japanese version (SWNS-J) | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical Global Impression–Schizophrenia (CGI-SCH), Global Assessment of Functioning (GAF) | — |
Countries
Japan
Outcome results
None listed