Comparison of efficacy between fixed combination of latanoprost/timolol + dorzolamide and fixed combination of dorzolamide/timolol + latanoprost in glaucoma patients with a histry of treatment with three unfixed eyedrops.

Comparison of efficacy between fixed combination of latanoprost/timolol + dorzolamide and fixed combination of dorzolamide/timolol + latanoprost in glaucoma patients with a histry of treatment with three unfixed eyedrops. - Comparison of efficacy between two different fixed combination eyedrops.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000006007

Enrollment

Registered

2011-07-21

Start date

2011-07-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

glaucoma

Interventions

Eye drops of fixed combination of latanoprost/timolol + dorzolamide. Tree-month observation. Eye drops of fixed combination of dorzolamide/timolol + latanoprost. Tree-month observation.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with primary open-angle glaucoma whose intraocular pressures are controlled by unfixed combination of latanoprost, timolol, and dorzolamide/brinzolamide.

Exclusion criteria

Exclusion criteria: 1) Patients with contraindication or careful administration in adopted eye drops. 2) MD value <-15 dB in Humphrey visual field analyzer. 3) Best corrected visual acuity <0.5. 4) Spherical equivalent <-9D or >9D. 5) Difference of spherical equivalent between right and left eye >3D 6) Patients with corneal abnormality that hinders intraocular pressure-measurement. 7) Insufficient mydriasis that inhibit observation of optic nerve disc. 8) Histry of ocular surgery and/or laser treatment except cataract surgery. 9) Retinal disease that affect visual field. 10) Patients who are considerd as appropriate by doctors in charge.

Design outcomes

Primary

Measure	Time frame
intraocular pressure	—

Countries

Japan

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026