Influence of angiotensin receptor blocker and direct renin inhibitor on renin-angiotensin-aldosterone system and left ventricular remodeling in patients with hypertension who underwent cardiac surgery

Influence of angiotensin receptor blocker and direct renin inhibitor on renin-angiotensin-aldosterone system and left ventricular remodeling in patients with hypertension who underwent cardiac surgery - Influence of angiotensin receptor blocker and direct renin inhibitor on renin-angiotensin-aldosterone system and left ventricular remodeling in patients with hypertension who underwent cardiac surgery

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000005966

Enrollment

100

Registered

2011-07-12

Start date

2010-12-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertension

Interventions

Olmesartan 40mg Olmesartan 20mg+Aliskiren 150mg

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients undergoing Cardiac surgery Hypertensive patients (>125mmHg in systolic blood pressure) by Olmesatan (20mg/day). Patients from whom informed consent was obtained

Exclusion criteria

Exclusion criteria: Patients who are pregnant or have possibility of pregnancy and are lactation period Patients who have hyperkalemia Patients who haverenal vascular hypertension Patients who have secondary hypertension Patients who were deemed not appropriate to participate in this study by doctor

Design outcomes

Primary

Measure	Time frame
1) RAAS 2) BNP	—

Secondary

Measure	Time frame
1) serum Cr 2) UCG (LVMI, EF) 3) Urinary albumin 4) cystatin C 5) Blood pressure, Heart rate	—

Countries

Japan

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026