Effects of monosodium glutamate (MSG) on taste function, expression of taste receptor mRNA of tongue and malnutorition in patients with head and neck cancer after chemotherapy.

Effects of monosodium glutamate (MSG) on taste function, expression of taste receptor mRNA of tongue and malnutorition in patients with head and neck cancer after chemotherapy. - Effects of MSG on taste, taste receptor gene expression and malnutorition in patients with head and neck cancer.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000005885

Enrollment

Registered

2011-06-29

Start date

2011-08-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

head and neck cancer

Interventions

Self-supplementation of MSG on hospital meal

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Adult patients with head and neck cancer that is pathologically diagnosed complaining of chemotherapy-induced poor appetite of which grade over I estimated by Common Terminology Criteria for Adverse Events (version 4).

Exclusion criteria

Exclusion criteria: 1) Patients who have ever suffered from adverse event of MSG. 2) Patients who was excluded by investigators.

Design outcomes

Primary

Measure	Time frame
The function of taste including umami and the expression of taste receptor mRNA of the tongue	—

Secondary

Measure	Time frame
Body weight, levels of total protein and albumin in the serum and QOL concerning about nutrition.	—

Countries

Japan

Contacts

Public ContactYoshiaki Kitamura

University of Tokushima School of Medicine Department of Otolaryngology

ykitamura@tokushima-u.ac.jp088-633-7169

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026