Effects of nonbenzodiazepine, melatonin receptor agonist, and Kampo medication on sleep disturbances in perimenopausal and postmenopausal women

Effects of nonbenzodiazepine, melatonin receptor agonist, and Kampo medication on sleep disturbances in perimenopausal and postmenopausal women - Effects of nonbenzodiazepine, melatonin receptor agonist, and Kampo medication on sleep disturbances in perimenopausal and postmenopausal women

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000005882

Enrollment

Registered

2011-07-01

Start date

2011-07-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

climacteric syndrome insomnia

Interventions

4-week treatment with zolpidem 5 mg/day 4-week treatment with ramelteon 8 mg/day 4-week treatment with yokukansan 7.5 g/day

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: women who visit our menopause clinic and have moderate to severe sleep disturbances

Exclusion criteria

Exclusion criteria: (1) those who receive fluvoxamine (2) those who have severe liver damage (3) those who have severly impaired lung function (4) those who have myasthenia gravis (5) those who have acute angle-closure glaucoma

Design outcomes

Primary

Measure	Time frame
subjective and objectivd sleep parameters	—

Secondary

Measure	Time frame
menopausal symptoms	—

Countries

Japan

Contacts

Public ContactMasakazu Terauchi

Tokyo Medical and Dental University Department of Obstetrics and Gynecology

m.terauchi.gyne@tmd.ac.jp03-3813-6111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026