Effects of hormone therapy and keishibukuryogan on blood pressure in perimenopausal and postmenopausal women

Effects of hormone therapy and keishibukuryogan on blood pressure in perimenopausal and postmenopausal women - Effects of hormone therapy and keishibukuryogan on blood pressure in perimenopausal and postmenopausal women

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000005868

Enrollment

Registered

2011-07-01

Start date

2011-07-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

climacteric syndrome hypertension

Interventions

4-week treatment with micronized estradiol 1 mg/day 4-week treatment with keishibukuryogan 7.5 g/day

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: women who are bothered by menopausal symptoms and have hypertension or high-normal blood pressure

Exclusion criteria

Exclusion criteria: (1) past history of breast cancer, endometrial cancer, coronary heart diseases, stroke, or vascular thromboembolism (2) current use of antihypertensives (3) current use of hormone therapy or Kampo medicines (4) past history of allergy or liver dysfunction by the use of estrogens, progestins, or Kampo medicines

Design outcomes

Primary

Measure	Time frame
menopausal symptoms blood pressure	—

Countries

Japan

Contacts

Public ContactMasakazu Terauchi

Tokyo Medical and Dental University Department of Obstetrics and Gynecology

m.terauchi.gyne@tmd.ac.jp03-3813-6111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026