Knee joint pain Chronic muscular pain
Conditions
Interventions
Traditional Chinese medicine
Sponsors
Tana orthopedic surgery
Kitashinyokohama orthopedic surgery
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Subjects from 40 to 74 years old 2) Knee joint pain with more than 20mm/100mm at VAS scale 3) Kellgren-Lawrence grade 0–III (mainly K/L grade 0-II) 4) Chronic muscular pain (neck stiffness)
Exclusion criteria
Exclusion criteria: 1) Other joint pain 2) 30 score on JOA (pain, walking ability) 3) Hyperuricemia, gouty attack 4) Positive rheumatoid factor 5) Knee joint surgery 6) Hyaluronic acid, glucosamine, chondroitin sulfate 7) Treated with medicine for knee join pain and chronic muscular pain 8) Bisphosphonate, hormonal therapy 9) Joint injection with hyaluronic acid or steroid 10) Occasional strenuous exercise 11) Bone disorders 12) Allergic 13) Malignant tumor, severe hypertension, heart disease, renal dysfunction, thyroid dysfunction, liver disease 14) Lactating, pregnant 15) Swelling 16) Treated with Chinese medicine 17) Treated with herbal medicine 18) Treated with sympathomimetic agent 19) Treated with medicine promoting reduction of levels of potassium in blood 20) Without ability of agreement or complaining 21) Alcoholism 22) Judged as unsuitable for this study based on the results of questionnaire 23) Judged as unsuitable for this study based on the results of clinical examination 24) 200 mL of blood donation 25) BMI of more than 35 26) Participant of other clinical trials 27) Judged as unsuitable for this study by the doctor
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| JKOM JOA VAS | — |
Secondary
| Measure | Time frame |
|---|---|
| Biomarker Muscular rigidity Blood flow Endothelial function | — |
Countries
Japan
Outcome results
None listed