Effects of calcium channel blockers on glucose tolerance and endothelial function in non-diabetic patients with essential hypertension: a comparative study between Azelnidipine and amlodipine on Glucose tolerance and Endothelial functioN - a crossover Trial (AGENT)

Effects of calcium channel blockers on glucose tolerance and endothelial function in non-diabetic patients with essential hypertension: a comparative study between Azelnidipine and amlodipine on Glucose tolerance and Endothelial functioN - a crossover Trial (AGENT) - AGENT

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000005837

Enrollment

Registered

2011-06-26

Start date

2008-03-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertension

Interventions

amlodipine 5mg azelnidipine 16mg

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Age >= 20 years old 2. Hypertensive patient with achievement of JSH 2009 goal 3. Treated with 5mg/day of amlodipine for more than 3 months

Exclusion criteria

Exclusion criteria: 1. Patients with history of allergy for the study drugs 2. Patients with history of cardiovascular disorders within 3 months 3. Patients with diabetes 4. Patients with serum creatinine >= 2.0mg/dl 5. Patients with systemic diseases 6. Patients with history of gastrointestinal surgery 7. Patients who are judged inappropriate for entry into this study by the investigator

Design outcomes

Primary

Measure	Time frame
1. Blood pressure and heart rate 2. 75g OGTT 3. Endothelial function	—

Secondary

Measure	Time frame
oxidative stress marker, inflammatory marker, circulating number of progenitor cells	—

Countries

Japan

Contacts

Public ContactKosuke Fukao

Juntendo University School of Medicine Department of Cardiovascular Medicine

03-3813-3111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026