A randomized multi-centered study to prove the effectiveness of combination therapy with topical Nadifloxacin and adapalene gel 0.1% for acne vulgaris

A randomized multi-centered study to prove the effectiveness of combination therapy with topical Nadifloxacin and adapalene gel 0.1% for acne vulgaris - A randomized multi-centered study to prove the effectiveness of combination therapy with topical Nadifloxacin and adapalene gel 0.1% for acne vulgaris

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000005810

Enrollment

Registered

2011-07-01

Start date

2011-07-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acne valgaris patients over 12 years old. (moderately- severe patients)

Interventions

1.Design of study multi-centered,randomization by way of an envelope,2-group comparison study 1.Design of study multi-centered,randomization by way of an envelope,2-group comparison study 2.numbe

75%=very good,50to&lt

75%=good,25to&lt

50%=usually,&lt

25% or becoming worse=Not good We assessment in 4grade. We assessment the lesion (erythema,scale,dry,burning,itching) about 4 grade(nothing, slightly,moderate,severe)in the ovservation days. 4

t feel it at all) 7)The final efficacy We examined the clinical change of ski lesions in the final ovservation day: very effactive,effective,slightly effective,no change,worse,unchanged:5grade

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Acne valgaris patients over 12 years old (moderately - severe)

Exclusion criteria

Exclusion criteria: Slightly acne,electrical acne, secondary acne,the most severe acne,slightly acne Patients who taking medicine orally for acne desease. Pregnant woman and likely to be pregnant or hope to be pregnant. Patients who weres a mustache

Design outcomes

Primary

Measure	Time frame
We examine the decrease rate of the number of inflammatory lesion. Count inflammatory lesions(Watching) and judgement of photograph. (take a photo on the one side of the face and fixed the photo place)	—

Secondary

Measure	Time frame
Skin symptoms:erythema,scale,dryness,urtication,itching 4grade Patients opinionpoll:erythema,scale,dryness,urtication,itching 5grade Applicate condition:Physical examination Bacteriologic survey Safety:survey an adverse event	—

Countries

Japan

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026