A single-blind and crossover study examining the efficacy of intranasal oxytocin administration for social impairments in subjects with pervasive developmental disorders

A single-blind and crossover study examining the efficacy of intranasal oxytocin administration for social impairments in subjects with pervasive developmental disorders - Pilot study examining the efficacy of intranasal oxytocin administration for social impairments in subjects with pervasive developmental disorders

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000005809

Enrollment

Registered

2011-06-21

Start date

2011-06-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pervasive developmental disorders

Interventions

Single intranasal administration of 24 units oxytocin (Syntocinon spray) Single intranasal administration of placebo

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: 1) Subjects diagnosed with high-functioning autism, Asperger disorder, or pervasive developmental disorder not otherwise specified using DSM-IV 2) Subjects with normal intelligent total IQ > 80 measured with Wechsler Adult Intelligent Scale

Exclusion criteria

Exclusion criteria: 1) History of allergy for oxytocin 2) Cannot enter Magnetic Resonance Scanner 3) History of traumatic brain injury with any known cognitive consequences or loss of consciousness for more than 5 minutes 4) History of substance abuse or addiction 5) Instabilized with psychiatric comorbidity

Design outcomes

Primary

Measure	Time frame
psychological tasks related to social skills (face and facial expression recognition task, inference task utilizing social context), NIRS and eye tracking data	—

Secondary

Measure	Time frame
self rating scales, such as AQ(Autism Quatient), PARS(Pervasive Developmental Disorders Autism Society Japan Rating Scale), EPQ(Eysenck personality questionnaire), SPQ(Schizotypal Personality Questionnaire), TCI(Schizotypal Personality Questionnaire),SIQ(Social Intelligence Quantity)	—

Countries

Japan

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026