DNA mismatch repair (MMR) protein immunohistchemistry of hereditary non-polyposis colorectal cancer (HNPCC) related tumors and genetic analysis of MMR gene mutations.

DNA mismatch repair (MMR) protein immunohistchemistry of hereditary non-polyposis colorectal cancer (HNPCC) related tumors and genetic analysis of MMR gene mutations. - DNA mismatch repair status of HNPCC related tumors

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000005785

Enrollment

Registered

2011-06-29

Start date

2008-11-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

HNPCC related tumor

Interventions

IHC of MMR proteins, genetic or epigenetic analyses of MMR genes

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients fulfilled Amsterdam criteria I, II or Bethesda guideline. Patients suspected HNPCC or related syndrome such as Muir-Torre syndrome or Turcot syndrome. Patients with written informed consent form.

Exclusion criteria

Exclusion criteria: Patients with no available sample. Patients without written informed consent form.

Design outcomes

Primary

Measure	Time frame
Screening of HNPCC related tumors by IHC for loss of MMR protein expression and observation of the clinical features assciated with MMR deficiency.	—

Countries

Japan

Contacts

Public ContactHideki Shimodaira

Institute of Development, Aging and Cancer, Tohoku University Department of Clinical Oncology

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026