type 2 diabetes
Conditions
Interventions
50 - 100mg of sitagliptine for 12 weeks
Sponsors
Juntendo University Graduate School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. The type 2 diabetic patients whose HbA1c are between 6.5 % and 8.0%. 2. The patients with fatty liver. 3. The patients who have already started diet and exercise therapy for more than 6 months. 4. The patients who are more than 20 year-old. 5. Male or Female 6. The patients who are able to read and understand the written informed consent.
Exclusion criteria
Exclusion criteria: 1) Type 1 diabetes 2) Heavy alcohol drinker 3) Patients who have serious liver disease 4) Patients who have serious kidney disease 5) Patients who have serious heart disease ( patients who have apparent heartfailure or myocardial infarction within 3 months) 6) Patients who have serious pancreatic disease 7) Patients with cancer 8) Patients who have viral infection (HBV,HCV) 9) Patients with serious diabetic complications including progressed neutopathy and proliferative retinopathy 10) Patietns with serious infection, inflammation, or injuary. pre- or post- operative state 11) Patients who have inflammatory bowel disease, ulcer in bowel, ileus and high risk for ileus 12) Patients who are pregnant, hope to be pregnant, or are in lactation period 13) Patients who take pioglitazone 14) Patients who are not applicable to this study judged by the medical doctor.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intrahepatic lipid, intramyocellular lipid Glucose metabolism after oral glucose load HbA1c | — |
Secondary
| Measure | Time frame |
|---|---|
| Liver function test Body weight Body fat Visceral fat, subcutaneous fat volume | — |
Countries
Japan
Outcome results
None listed