Effect of Angiotensin II receptor blockers in hypertensive patients with persistent atrial fibrillation after electrical defibrillation

Effect of Angiotensin II receptor blockers in hypertensive patients with persistent atrial fibrillation after electrical defibrillation - Effect of Angiotensin II receptor blockers in hypertensive patients with persistent atrial fibrillation after electrical defibrillation

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000005664

Enrollment

Registered

2011-06-01

Start date

2011-07-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

persistent atrial fibrillation

Interventions

Losartan group Non-RA inhibitor group

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) patients with persistent atrial fibrillation 2) Hypertensive patients 3) patients planned to be treated with electrical defibrillation 4) patients aged 20 years or older 5) patients who gave their written informed consent to participate

Exclusion criteria

Exclusion criteria: 1) patients with poorly-controlled hypertension (DBP>120 mmHg) 2) patients with complications whose condition is unstable 3) patients with severe renal function impairment or hepatic function impairment 4) patients who are or may be pregnant or lactating 5) patients with a history of allergic reaction to the drug used in the study 6) patients with hyperkalemia 7) patients who are judged to be inappropriate for the entry into the study by the investigator

Design outcomes

Primary

Measure	Time frame
Changes in serum metabolome	—

Secondary

Measure	Time frame
hs-CRP ANP,BNP Changes in blood-pressure level P Wave Signal-Averaged Electrocardiogram Echocardiographic indices Recurrence of atrial fibrillation	—

Countries

Japan

Contacts

Public ContactAsumi Takei

Kobe University Graduate School of Medicine Division of Cardiovascular Medicine

asumit@med.kobe-u.ac.jp078-382-5846

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026