knee osteoarthritis
Conditions
Interventions
1)COX-2 selective inhibitor group (36 cases) A fixed daily dose of COX-2 selective inhibitor, celecoxib (200mg/day in 2 divided doses) will be administered orally for 3 months.
2)Hyaluronan acid gro
Sponsors
Teikyo University Chiba Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Of knee osteoarthritis patients treated at the Chiba Medical Center on an outpatient basis, those who satisfy all the following inclusion criteria and do not meet any of the following exclusion criteria will be selected. A total of 72 subjects will be enrolled. 1) Diagnosed as knee osteoarthritis with Kellgren & Lawrence grade of I to III by simple X-ray imaging of knee joint in the upright and frontal position at the first visit 2) Written informed consent 3) Age: &#61619;20 years and <75 years 4) Exercise pain or rest pain for more than 3 months
Exclusion criteria
Exclusion criteria: Patients who meet any of the following exclusion criteria will not be enrolled in this research study. 1) History of hypersensitivity to any components of the investigational products to be used in this research study 2) History of hypersensitivity to any other medicinal products 3) Women who are pregnant, breastfeeding, or planning to become pregnant during the study period. 4) Secondary knee osteoarthritis due to trauma or other diseases 5) History of surgery of the involved knee joint (including arthroscopy) 6) Conservative therapy of the involved knee joint within one month of enrollment in this study 7) Diseases in the involved knee joint other than those associated with osteoarthritis, e.g., injury of semi-lunar disc, ligament injury, and cartilage injury 8) Serious renal, hepatic, and/or cardiovascular disease 9) Significant mental disorder, drug dependence, and/or alcohol abuse 10) Patients who are unable to come to the medical center for all scheduled visits 11) Other patients considered to be ineligible for this research study by the investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MRI examination with T2 mapping | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) MRI examination with Modified Outerbridge classification (T1 weighted image, T2 weighted image, etc.), 2) simple X-ray examination with Kellgren-Lawrence classification, 3) assessment of clinical symptoms using JKOM (Japanese Knee Osteoarthritis Measure), Lysholm score, and VAS (visual analogue scale. | — |
Countries
Japan
Outcome results
None listed