Effects of sitagliptin and vildagliptin on glucose fluctuations in patients with type 2 diabetes -prospective open-label controlled study-

Effects of sitagliptin and vildagliptin on glucose fluctuations in patients with type 2 diabetes -prospective open-label controlled study- - Effects of sitagliptin and vildagliptin on glucose fluctuations in patients with type 2 diabetes

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000005627

Enrollment

Registered

2011-06-01

Start date

2011-06-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

type 2 diabetes mellitus

Interventions

vildagliptin sitagliptin

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) patients with type 2 diabetes using sitagliptin (50mg, once daily) or vildagliptin(50mg, twice daily) for more than 3 months 2) HbA1c 5.8-7.9% (JDS), HbA1c 6.2-8.3%(NGSP) 3) written informed consent

Exclusion criteria

Exclusion criteria: 1) patients who received insulin injection therapy 2) severe hepatic dysfunction, renal dysfunction, heart failure 3) history of anaphylaxis of Sitagliptin or Vildagliptin, 4) pregnancy and lactation 5) patients who are inadequate to enter this study due to the other reasons by physician's judgments

Design outcomes

Primary

Measure	Time frame
To evaluate changes in MAGE; mean amplitude of glycemic excursions before and after switching from sitagliptin to vildagliptin, and vice versa	—

Secondary

Measure	Time frame
1) M-value 2) fasting plasma glucose, HbA1c, glycoalbumin 3) beta cell function 4) changes in body weight, Body Mass Index, abdominal girth, blood pressure 5) several biomarkers	—

Countries

Japan

Contacts

Public ContactHideaki Miyoshi

Hokkaido University Hospital Department of Medicine II

hmiyoshi@med.hokudai.ac.jp011-706-5915

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026