The study of physiological stress and recovery condition between AOP vs. TIVA for ambulatory general anesthesia to dental patient -Salivary alpha-amylase level and activity of autonomic nervous system were measured for mental retardation and autism patient-

The study of physiological stress and recovery condition between AOP vs. TIVA for ambulatory general anesthesia to dental patient -Salivary alpha-amylase level and activity of autonomic nervous system were measured for mental retardation and autism patient- - The study of physiological stress and recovery condition for ambulatory general anesthesia

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000005615

Enrollment

Registered

2011-05-17

Start date

2011-05-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

dental patients with mental retardation and/or autism

Interventions

AOP group Patients receive sevoflurane induction. Then we stop sevoflurane after having venous line and 2mg/kg propofol, 10mg/kg/h rocuronium administer for LMA insertion. They receive 2 l/min air, 1

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: ASA class 1 or 2 mental retardation and autism patients who scheduled for dental procedure under general anesthesia.

Exclusion criteria

Exclusion criteria: Body weight under 10kg Heart disease over NYHA class 2 Taking psychotropics Having drug allergy Cannot take IC of guardian

Design outcomes

Primary

Measure	Time frame
salivary alpha-amylase discharge time	—

Secondary

Measure	Time frame
heart rate variability incident of PONV	—

Countries

Japan

Contacts

Public Contactsunada katsuhisa

The nippon dental university department of dental anesthesiology

katsu.sunada@nifty.com03-3261-8311

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026