diabetic nephropathy
Conditions
Interventions
continuous infusion of 0.01 to 0.02 micro gram/body weight (kg)/min of Carperitide for three days
Sponsors
Kanazawa University, Graduate School of Internal Medicine, department of internal medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: study subjects should meet the criteria below; serum creatine greater than 1.7mg/dl to less than 4.0mg/dl, and urinary protein amount greater than 1 gram per 1 gram of urinary creatinine.
Exclusion criteria
Exclusion criteria: exclusion criteria are shown as below; subjects with decreased hepatic metabolism including acute hepatitis, exaggerated phase of chronic hepatitis, liver cirrhosis, hepatocellular carcinoma and jaundice, women with pregnancy and its possibility or lactation and subjects whom the attending doctor considered as non-suitable for the entry for this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| change of renal functions related parameters including Cr, BUN, cystatin C, urinary protein excretion and urinary albumin excretion | — |
Secondary
| Measure | Time frame |
|---|---|
| change of the markers reflecting lipoprotein metabolism; T-cho, TG, LDL-C, sdLDL=small dense LDL, pre-beta1-HDL change of blood pressure change of Renin-angiotensin-aldosterone system related parameters; Plasma renin activity, aldosterone concentration change of oxidative stress related markers; urinary 8-OHdG excretion, urinary isoprostane | — |
Countries
Japan
Contacts
Public ContactKunimasa Yagi
Kanazawa University Hospital department of endocrinology and metabolism
Outcome results
None listed