Ischemic heart disease
Conditions
Interventions
One year Fluvastatin (30mg) and Ezetimibe (10mg)
One year Fluvastatin (30mg) alone
Sponsors
Toyohashi Heart Ceter, Cardiovascular Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Stable angina pectoris 2) All patients have 1 or 2-vessel diseases and were good candidates for percutaneous coronary intervention. 3) Target vessel for VH IVUS and OCT interrogation must not have undergone angioplasty or have more than 50% luminal narrowing throughout a target segment with a minimum length of 30mm 4) Target vessel for VH IVUS and OCT interrogation had mild-to-moderate vessel tortuosity and calcification 5) Left ventricular ejection fraction >30%
Exclusion criteria
Exclusion criteria: 1) Unstable angina or myocardial infarction within the previous 4 weeks 2) Significant stenotic lesions in all coronary vessels 3) Target vessel for VH IVUS and OCT interrogation had lesions with angiographically detected thrombus 4) Contra-indications to IVUS and OCT examination 5) Other concomitant diseases or medical condition that could impact patient/procedural outcomes, such as history of bleeding diathesis,stroke, or transient ischemic neurological attacks within the past year or hypersensitivity to heparin, aspirin, ticlopidine, or X-ray contrast media 6) Secondary causes of hyperlipid-emia or uncontrolled triglyceride level above 500 mg/dl 7) A positive pregnancy test.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| OCT and VH IVUS findings at one year. 1. Thickness of fibrous cap in OCT 2. %necrotic core volume in VH 3. the incidence of thin-cap fibroatheroma in OCT and VH findings | — |
Countries
Japan
Outcome results
None listed