chronic kidney disease
Conditions
Interventions
5h-HS (intravenous hydration with isotonic saline for 5 hours before contrast exposure and for 24 hours after contrast exposure)
20h-HS (intravenous hydration with isotonic saline for 20 hours befor
Sponsors
Oita Nakamura Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria were as follows: age of 20 - 85 years; estimated glomerular filtration rate (eGFR) of 15-60 L/min/1.73 m2.
Exclusion criteria
Exclusion criteria: Exclusion criteria were as follows: emergency coronary arteriography or percutaneous coronary intervention, allergy to contrast mediums, pregnancy, intravascular administration of contrast mediums within the preceding 5 days of the study, acute coronary syndrome within the preceding 1 month of the study, severe symptoms of heart failure (New York Heart Association functional class IV), left ventricular ejection fraction <25%, severe hepatic insufficiency, severe chronic respiratory disease, single function kidney, dialysis, and administration of N-acetylcysteine, theophylline, dopamine, or mannitol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint was the absolute and % maximal changes in serum creatinine from the baseline up to 48 hours after contrast exposure. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary endpoints were the incidence of CIN defined as a &#8805;25% increase in serum creatinine within 48 hours. | — |
Countries
Japan
Contacts
Public Contactkumie torigoe
Oita Nakamura Hospital Division of Cardiovascular Medicine
Outcome results
None listed