1.Hypertensive patients with diabetes mellitus (DM), pre-diabetes: DM was defined as at least one of the following criteria: fasting blood glucose >
Conditions
Interventions
Sponsors
Jichi Medical University School of Medicine
International University of Health and Welfare Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Hypertension with dibetes mellitus or pre-diabetes. 2. Morning systolic blood pressure >=135 with self-monitoring BP at home 3. The age >=30 years 4. The patients were either never treated, single drug therapy (CCB or ACE-I, ARB), or double drug therapy in combination with CCB plus ACE-I, ARB.
Exclusion criteria
Exclusion criteria: 1. Secondary hypertension 2. Patients with congestive heart failure, acute MI less than 6months, acute stroke less than 6months, atrial fibrilation, AV block, or significant arrhythmia. 3.Hepatic damage (AST, ALT >twice of upper limits, renal dysfunction (serum creatine 4. Allergy, or allergic reaction 5. Dementia from whom we cannot obtain informed consent. 6. pregnancy 7. for whom the attending doctor considerd he or she is not appropriate for the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| BP control rate: the percentage of attaining target home BP <125/75mmHg | — |
Secondary
| Measure | Time frame |
|---|---|
| BP: BP control rate and the degree of BP lowering at the end of the treatment Renal function: the changing rate of serum creatinine (eGFR) and urinary microalbumin Diabetes: changing rate of HbA1c and fasting blood glucose Pulse wave velocity (PWV) Augmentation index at radial artery Baroreflex sensitivity (BRS) Flow mediated dilatation (FMD) | — |
Countries
Japan
Contacts
Public ContactKazuo Eguchi
Jichi Medical University School of Medicine Division of Cardiovascular Medicine, Departmentof Medicine
Outcome results
None listed