Utility of contrast-enhanced intraoperative ultrasound using Sonazoid in patients undergoing surgery for liver metastasis from colorectal carcinoma - comparison with Gd-EOB-DTPA-MRI, contrast enhanced MDCT, and extracorporeal ultrasound-

Utility of contrast-enhanced intraoperative ultrasound using Sonazoid in patients undergoing surgery for liver metastasis from colorectal carcinoma - comparison with Gd-EOB-DTPA-MRI, contrast enhanced MDCT, and extracorporeal ultrasound- - Contrast-enhanced intraoperative ultrasound using Sonazoid in patients with liver metastasis from colorectal carcinoma

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000005537

Enrollment

100

Registered

2011-05-01

Start date

2011-05-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver metastasis from colorectal carcinoma

Interventions

Contrast-enhanced intraoperative ultrasound

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: * Planned to undergo hepatic resection for liver metastasis from colorectal carcinoma * Age 20 years or more * Written informed consent is gained

Exclusion criteria

Exclusion criteria: * History of allergy against Sonazoid or an egg * Contrast-enhanced MDCT or Gd-EOB-DTPA-MRI is impossible based on history of allergy or renal dysfunction * 10 or more liver metastases * Arterio-venous shunt in heart or lung * Severe heart disease * Severe pulmonary disease * Pregnant patients * Nursing mothers * Attending physician or the operator consider the study hazardous

Design outcomes

Primary

Measure	Time frame
*Frequency that contrast-enhanced intraoperative ultrasound alone finds new liver metastases that have not been detected by preoperative imaging studies or intraoperative ultrasound	—

Secondary

Measure	Time frame
Diagnostic abilities for liver metastasis of contrast-enhanced intraoperative ultrasound, Gd-EOB-DTPA-MRI, contrast-enhanced MDCT, extracorporeal contrast-enhanced ultrasoud and intraoperative ultrasoud Diagnostic ability of contrast-enhanced intraoperative ultrasound among new focal liver lesions that are found by intraoprative ultrasound *Frequency that the planned surgical precedure is altered through contrast-enhanced intraoperative ultrasound	—

Measure

Time frame

*Diagnostic abilities for liver metastasis of contrast-enhanced intraoperative ultrasound, Gd-EOB-DTPA-MRI, contrast-enhanced MDCT, extracorporeal contrast-enhanced ultrasoud and intraoperative ultrasoud *Diagnostic ability of contrast-enhanced intraoperative ultrasound among new focal liver lesions that are found by intraoprative ultrasound *Frequency that the planned surgical precedure is altered through contrast-enhanced intraoperative ultrasound

—

Countries

Japan

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026