Psychiatric emergency multi-center randomized clinical trial on unanswered questions of pharmacotherapy in acute-phase schizophrenia

Psychiatric emergency multi-center randomized clinical trial on unanswered questions of pharmacotherapy in acute-phase schizophrenia - Psychiatric emergency multi-center RCT of antipsychotic high dose

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000005526

Enrollment

200

Registered

2011-05-31

Start date

2011-06-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

schizophrenia, schizophreniform disorder, schizoafective disorder

Interventions

olanzapine up to 40mg risperidone up to 12mg

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who are admitted to psychiatric emergnecy hospitals due to acute-psychotic state, diagnosed as DSM-IV: 295.xx

Exclusion criteria

Exclusion criteria: 1) severe liver, renal, heart, or respiratory dysfunction 2) diabetes mellitus, or its history 3) pregnant, nursing, or desiring to be pregnant

Design outcomes

Primary

Measure	Time frame
(1) rate of 50% improvement in PANSS total score (2) rate of treatment discontinuation for any cause	—

Secondary

Measure	Time frame
(1) torelability (DIEPSS, rate of treatment discontinuation for adverse event), change in vital signs and weight (2) improvement in symptoms (PANSS total, subscales, CGI, GAF)	—

Countries

Japan

Contacts

Public ContactKotaro Hatta

Juntendo University Faculty of Medicine Juntendo University Nerima Hospital

khatta@juntendo.ac.jp03-5923-3111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026