The role of long-term use of noninvasive ventilation in patients with severe chronic obstructive pulmonary disease

The role of long-term use of noninvasive ventilation in patients with severe chronic obstructive pulmonary disease - The trial of long use of noninvasive ventilation for severe COPD

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000005519

Enrollment

Registered

2011-05-01

Start date

2011-05-06

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic obstructive pulmonary disease (COPD)

Interventions

start nocturnal use of NIV. We set the pressure support as much as patients are tolerable. continue the current treatments

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.He or she has to have the diagnosis of COPD. 2.more than 10 years smoking story 3.The current treatment should be continued more than 3 months 4.In pulmonary lung function test,FEV1/FVC less than 60% and FEV1 more than 1.5L 5.In arterial blood gas analysis PaCO2 more than 45mmHg and pH more than 7.30 6.clinicaly stable for more than 4 weeks

Exclusion criteria

Exclusion criteria: 1.The patiens whose FEV1/FVC improved more than 15% with short acting bronchodailative agents. 2.current-smoker 3.The patients complicated with sleep apnea syndrome 4.patients taking regular systemic steriods 5.pneumothorax within 6 months 6.patients complicated with other choronic pulmonary syndromne 7.patients complicated with severe heart failure 8.patients complicated with infection and malignant diseases

Design outcomes

Primary

Measure	Time frame
Blood carbon dioxide level	—

Secondary

Measure	Time frame
Lung function(FEV1, FEV1/FVC) 6 minutes walk test Health related QOL The numbers of events of acute deterioration	—

Countries

Japan

Contacts

Public ContactKimihiko Murase

Kyoto University Graduated School of Medicine Depatment of respiratory medicine

kmurase@kuhp.kyoto-u.ac.jp81-75-751-3852

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026