Patients with coronary artery disease
Conditions
Interventions
Sponsors
Hiroshima University hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Patients with coronary artery disease planed PCI only LCA 2.Hypercholesterolemia patients Meeting one of following criteria a)TC is 220 mg/dL or over b)LDL-C is 140 mg/dL or over c)LDL-C is 100 mg/dL or over or TC is 180 mg/dL or over and requiring cholesterol lowering drugs judged by attending physicians 3.Age (20<= <80 year-old) 4.Patients given written informed consent
Exclusion criteria
Exclusion criteria: 1.A PCI target lesion with graft disease or in-stent restenosis 2.Patients who have skip lesion without PCI target lesion, and planed PCI within this examination. But it does not limit the PCI by a disease of the right coronary artery 3.Stent which is BMS to use for PCI 4.Malignant tumor in active phase 5.Patients who meet contraindication of LIVALO tablet below a)Patients who have hypersensitivity to LIVALO tablet b)Patients who have severe liver dysfunction or biliary atresia c)Patients who are being treated with cyclosporine d)Pregnant women, women suspected of being pregnant, or lactating women 6.Patients with hypersensitive to contrast media 7.Patients with liver dysfunction [ALT(GPT) 100 IU/L <=] 8.Patients undergoing dialysis 9.Patients with familial hypercholesterolemia 10.Patients who are ineligible in the opinion of the investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| A rate of change of Coronary blood flow by acetylcholine provocation | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.The changes in vessel diameter on target vessel and non-target vessel by acetylcholine provocation 2.The changes in TC, LDL-C, TG, HDL-C, non-HDL-C, LDL-C/HDL-C, RLP-C and MDA-LDL 3.The Correlation between change in lipid profiles and change in Coronary blood flow by acetylcholine provocation 4.The Correlation between change in lipid profiles and change in coronary blood vessel diameter of target vessel and non-target vessel by acetylcholine provocation 5.Changes in inflammation marker (hs-CRP) 6.The Correlation between change in inflammation marker and change in Coronary blood flow by acetylcholine provocation 7.The Correlation between change in inflammation marker and change in coronary blood vessel diameter of target vessel and non-target vessel by acetylcholine provocation 8.The incidence rate of adverse event 9.The changes in laboratory values | — |
Countries
Japan
Contacts
Public ContactSatoshi Kurisu
Hiroshima University hospital Department of Cardiovascular Medicine
Outcome results
None listed