malignant pleural mesothelioma
Conditions
Interventions
At first the maliganat pleural mesothelioma patient resistant to standard treatment receives F-BPA PET. Base upon the tumor to blood ration of F-BPA radioactivity, only the patient with T/B ratio over
Sponsors
Particle Radiation Oncology Research Center,Kyoto University Research Reactor Institute
Translational Research Informatics (TRI) center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1)Histopatholigical confirmation as malignant pleural mesothelioma 2)Resistant to PEM or PEM+CDDP chemotherapy 3)The tumor is located only in one side of thorax 4)IC possible person of 20 to 75 years old 5)ECOG Performance Status (PS) is 0 or 1 6)Clinical test are within following values. WBC more than 3,000 /micro-l Hb more than 8.0 g/dl Pt more than 100,000 /micro-l AST (GOT) less than 100 IU/l ALT (GPT) less than 100 IU/l Serum Creatinine less than 1.5 mg/dl
Exclusion criteria
Exclusion criteria: The patient to whom one of following criterias apply. 1)Either one among following conditions transdiaphrgm invasion to the abdomen direct invasion to opposite thorax invasuion to the mediastinum invasuion to the spine invasuion to the pericardium 2)Metastasis to the carina lymphnode 3)Distant metastasis 4)Previous radiotherapy to the thorax 5)Chemotherapy within 1 month at registration 6)Pregnant, possiblly pregnat or nursing woman 7)Phenylketonuria 8)Grade 3 or 4 in NYHA classification of cardiac performance 9)Doctors responsible for the study decide as wrong to the entry
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Adverse effects and their grade | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall survival time, progression free survival, regression of tumor, grade of pain | — |
Countries
Japan
Contacts
Public ContactKoji Ono
Kyoto University Research Reactor Institute Particle Radiation Oncology Research Center
Outcome results
None listed