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Mapping of brain cholinergic and dopaminergic alternations in rapid eye movement (REM) sleep behavior disorder by PET

Mapping of brain cholinergic and dopaminergic alternations in rapid eye movement (REM) sleep behavior disorder by PET - Mapping of brain cholinergic and dopaminergic alternations in RBD by PET

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000005475
Enrollment
65
Registered
2011-04-21
Start date
2011-04-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy volunteer, RBD and Parkinson&#39

Interventions

Sponsors

National Institute of Radiological Sciences (NIRS), National Institutes for Quantum and Radiological Science and Technology (QST)
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: [healthy volunteer] 50y.o.<=Age<=88y.o., cognitive normal subjects without severe physical complication [Rapid eye movement behavior disorder (RBD)] 50y.o.<=Age<=88y.o., patients diagnosed with RBD according to the International Clasiffication of Sleep Disorders: second edition (ICSD-2) [Westchester.2005] [Parkinson's disease (PD)] 50y.o.<=Age<=88y.o., patients diagnosed with PD according to UK brain bank Parkinson's disease diagnostic criteria [Hughes AJ.1992]

Exclusion criteria

Exclusion criteria: [RBD] [PD] 1.psychiatric complications such as drug abuse 2.other organic brain complications such as symptomatic stroke, PD-related disorders and other neurodegenrative diseases 3.severe physical complications 4.exclude the patients who are recognized as inadequate patients by doctors with resposibility in this study

Design outcomes

Primary

MeasureTime frame
Quantitative measurement of brain dopamine transporter binding and brain acetylcholinesterase activity in PET

Countries

Japan

Contacts

Public Contactkazuko Suzuki

QST Hospital, National Institutes for Quantum and Radiological Clinical Research Support Section

suzuki.kazuko@qst.go.jp+81-(0)43-206-3025

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026