type 2 diabetes mellitus
Conditions
Interventions
Acarbose 150-300mg/day for 3 months
Sitagliptin 100mg/day for 3 months
Sponsors
Saitama Medical University
Kumagaya Geka Hospita
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Type 2 Diabetes mellitus (HbA1c level: more than 6.5%, less than 10.0%) 2) Age more than 20 years 3) Patients who have been taking 50mg qd of sitagliptin for 3 months or more (50mg qd: half of approved maximum dose) 4) 2hr postprandial glucose levels: more than 200mg/dL 5) Fasting TG levels: more than 150mg/dL 6) Pts with written IC
Exclusion criteria
Exclusion criteria: 1) According to package insert descriptions (Severe ketosis, diabetic coma etc.) 2) Patients who use of other antidiabetic agents 3) Patients who use of fibrate 4) Gastrointestinal discomfort 5) Severe hepatic dysfunction or severe renal dysfunction 6) Patients judged by the investigator to be ineligible for some other reason
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lipid profile(pre-and post-meal(30min,1,2hours)triglyceride, pre- and post-meal(30min,1,2hours)chylomicron, pre- and post-meal(30min,1,2hours)VLDL, pre- and post-meal(30min,1,2hours)IDL, pre- and post-meal(30min,1,2hours)native LDL, pre- and post-meal(30min,1,2hours)small dense LDL, pre- and post-meal(30min,1,2hours)HDL | — |
Secondary
| Measure | Time frame |
|---|---|
| HbA1c, The blood glucose, insulin, proinsulin, GLP-1, GIP, glucagon level are measured before as well as after 0.5, 1, 2 hour after breakfast. | — |
Countries
Japan
Contacts
Public ContactIkuo Inoue
Saitama Medical University Dept. of Endocrinology and Diabetology
Outcome results
None listed