Hypertension
Conditions
Interventions
A standard dose ARB+Aliskiren 150mg/day
A high dose ABR monotherapy
Sponsors
Kanazawa Municipal Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Hypertensive patients who are older than 30 years. (2) Hypertensive patients whose blood pressure cannot achieve less than 140/90 mmHg under treatment with a standard dose of ARB over 4 weeks. (3) Outpatients who give written informed consent.
Exclusion criteria
Exclusion criteria: (1) Patients who have secondary hypertension (2) Patients with serum Cr =>2.0 mg/dL (3) Patients who have previous history of allergy to Aliskiren (4) Patients who are pregnant or have possibility of pregnancy and are lactation period (5) Patients who have ciclosporin or itraconazole (6) Patients who have bilateral or unilateral renal artery stenosis (7) Patients who have hyperkalemia (8) Patients who have nephrotic syndrome (9) Patients who were deemed not appropriate to participate in this study by doctor
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| (1) Change in blood pressure (2) Change in albuminuria | — |
Secondary
| Measure | Time frame |
|---|---|
| Change before and after treatment of the following items: (1) PRA, PAC, serum creatinine, potassium (2) Change in eGFR | — |
Countries
Japan
Contacts
Public ContactHiroshi Takakuwa
Kanazawa Municipal Hospital Department of Internal Medicine
Outcome results
None listed