ALI/ARDS due to sepsis
Conditions
Interventions
Freeze-Dried Sulfonated Human Normal Immunoglobulin
Sponsors
Division of Respirology, department of internal medicine, Jikei University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients clinically diagnosed as ALI / ARDS due to sepsis 2) Over 18 years of age, gender does not matter
Exclusion criteria
Exclusion criteria: 1) Patients with a history of allergy or shock to the components of the immune globulin 2) Patients with severe liver damage (for example: patients with cirrhosis), however, derived from liver failure include sepsis. 3) Patients with severe renal failure (for example: chronic dialysis patients), however, derived from kidney failure include sepsis. 4) Patients with sepsis due to hematological malignancies 5) Patients in the treatment of malignant tumors 6) Patients treated with immunosuppressive drugs such as cyclosporine 7) Patients with less than 1000 granulocytes / mm2 due to any reasons other than sepsis 8) Patients who develop chronic heart failure or acute myocardial infarction within the last six weeks 9) Patients who are judged to be inappropriate by doctor
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Variation of septic inflammation markers (IL-6, TNF-a, CRP, PCT, HMGB-1, etc.) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Duration to recover from ALI/ARDS 2) Duration to recover from SIRS 3) The survival rate after 30 days 4) The period of ventilator use [VFD (Ventilator Free Days): survival time in a state that seceded from the ventilator 28 days] 5) Inspection infections (WBC, neutrophil count, the number of peripheral blood lymphocytes, the serum IgG and albumin) | — |
Countries
Japan
Contacts
Public ContactYoshitaka Seki
Jikei University Daisan-Hospital Division of Respirology, department of internal medicine
Outcome results
None listed