Evaluation of effect of chemotherapy for depiction of metastatic liver tumor on gadoxetate disodium enhanced MRI

Evaluation of effect of chemotherapy for depiction of metastatic liver tumor on gadoxetate disodium enhanced MRI - Evaluation of effect of chemotherapy on gadoxetate disodium enhanced MRI

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000005401

Enrollment

Registered

2011-04-11

Start date

2011-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

metastatic liver tumor

Interventions

Patients with Lapatinib therapy or patients who are scheduled for Lapatinib therapy

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (a) Patients older than 20-year-old. (b) Patients with Lapatinib therapy or patients who are scheduled for Lapatinib therapy. (c) Patients whose body weight is lower than 100kg. (d) Patients with informed consent.

Exclusion criteria

Exclusion criteria: (a) Patients who are contraindicated in MRI examination (for example; patients with pace maker and claustrophobia patients). (b) Patients with history of severe side effect of gadolinium contrast media and gadoxetate disodium. (c) Patients with poor performance status. (d) Patients with bronchial asthma. (e) Patients with severe liver damage (Serum bilirubin > 2.0mg/dL). (f) Patients with severe kidney damage (eGFR < 30ml/min/1.73m2). (g) Gravid or lactating patients and patients who may be pregnant. (h) Patients whom their doctor decide to be inappropriate for this study.

Design outcomes

Primary

Measure	Time frame
To verify the change on enhancement pattern of liver and vessels, and also the change of capability of detection of tumor with gadoxetate disodium-enhanced MRI	—

Countries

Japan

Contacts

Public ContactYuko Nakamura

Hiroshima University Department of Diagnostic Radiology

yukon@hiroshima-u.ac.jp

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026